Roundworld is in trouble again, and this time it looks fatal. Having created it in the first place, the wizards of Unseen Univeristy feel vaguely responsible for its safety. They know the creatures who lived there escaped the impending Big Freeze by inventing the space elevator - they even intervened to rid the planet of a plague of elves, who attempted to divert humanity onto a different time track. But now it's all gone wrong - Victorian England has stagnated and the pace of progress would embarrass a limping snail. Unless something drastic is done, there won't be time for anyone to invent spaceflight and the human race will be turned into ice-pops.

Why, though, did history come adrift? Was it Sir Arthur Nightingale's dismal book about natural selection? Or was it the devastating response by an obscure country vicar called Charles Darwin, whose bestselling Theology of Species made it impossible to refute the divine design of living creatures? Either way, it's no easy task to change history, as the wizards discover to their cost. Can the God of Evolution come to humanity's aid and ensure Darwin writes a very different book? And who stopped him writing it in the first place?

Geoff Manaugh and Nicola Twilley have been researching quarantine since long before the COVID-19 pandemic. With Until Proven Safe, they bring us a book as compelling as it is definitive, not only urgent reading for social-distanced times but also an up-to-the-minute investigation of the interplay of forces–––biological, political, technological––that shape our modern world.

Quarantine is our most powerful response to uncertainty: it means waiting to see if something hidden inside us will be revealed. It is also one of our most dangerous, operating through an assumption of guilt. In quarantine, we are considered infectious until proven safe.

Until Proven Safe tracks the history and future of quarantine around the globe, chasing the story of emergency isolation through time and space—from the crumbling lazarettos of the Mediterranean, built to contain the Black Death, to an experimental Ebola unit in London, and from the hallways of the CDC to closed-door simulations where pharmaceutical execs and epidemiologists prepare for the outbreak of a novel coronavirus.

But the story of quarantine ranges far beyond the history of medical isolation. In Until Proven Safe, the authors tour a nuclear-waste isolation facility beneath the New Mexican desert, see plants stricken with a disease that threatens the world’s wheat supply, and meet NASA’s Planetary Protection Officer, tasked with saving Earth from extraterrestrial infections. They also introduce us to the corporate tech giants hoping to revolutionize quarantine through surveillance and algorithmic prediction.

We live in a disorienting historical moment that can feel both unprecedented and inevitable; Until Proven Safe helps us make sense of our new reality through a thrillingly reported, thought-provoking exploration of the meaning of freedom, governance, and mutual responsibility.